Creative Biolabs Releases One-stop HLA Typing and KIR Typing Services

NEW YORK, NY, UNITED STATES - Apr 27, 2020 - The chimeric antigen receptor T (CAR-T) cell immunotherapy covers a wide range of diseases, including acute leukemia, non-Hodgkin's lymphoma, and even tumors, autoimmune diseases, HIV, heart disease, etc., which makes it a research hotspot in the biological world.

With an unrelenting drive in the biotechnology research area, Creative Biolabs has been a world-renowned service provider for immunotherapy. Owning one of the world’s largest collection of CAR products, Creative Biolabs spares no effort to innovate the next generation CAR technologies to perfect the portfolio of one-stop CAR-T therapy development services, including virus packaging & CAR gene delivery, CART-T cell development, in vitro assay, clinical trial. etc. Now, it released the optimized HLA typing and KIR typing services to shape the best strategy for custom study and program design.

• HLA Typing Service

The Human Leukocyte Antigen (HLA) system is a series of major histocompatibility complex (MHC) proteins in humans, which plays an important role in the immune system in humans. Creative Biolabs has developed a dedicated NGS-based HLA typing service with precise and high-resolution results.

The workflow of Creative Biolabs is complete and standard, ranging from sample preparation, HLA PCR, library construction, NGS seq to data and bioinformatics analysis. To provide better services for researches related to disease defense, protection from cancers, organ transplant rejections and biomarkers, Creative Biolabs has extended the coverage of HLA types, including HLA-A, B, C, G, DRB1, DRB3, DRB4, DRB5, DQA1, DQB1, DPA1, DPB1.

• KIR Typing Service

Killer-cell immunoglobulin-like receptors (KIRs) can interact with major histocompatibility (MHC) class I molecules to mediate the inhibitory or activated natural killer (NK) cell activities. With advanced technology platforms and extensive expertise, Creative Biolabs is ready to provide high-quality KIR typing services.

The KIR typing services, including KIR typing at the DNA and mRNA level, as well as KIR phenotyping by FACS, allows the detection of all human KIR genes and alleles at the genomic DNA and transcriptomic mRNA level. A bettered High-Throughput Sequencing (HTS) platform is also developed to analyze the KIR genes at the highest resolution, which leads to 100% accuracy of the delivered results. 

“We have designed sequence-specific primers to analyze the KIR genes. We can also determine copy number by reading depth, and also high-resolution genotypes of all KIR genes by the HTS platform,” introduced by a senior scientist at Creative Biolabs.

The professional team of Creative Biolabs has accumulated years of experience and established the standard pipeline for both HLA and KIR typing services. Creative Biolabs is committed to ultra-high-resolution typing in a highly efficient way. If there are any queries, please visit https://www.creative-biolabs.com/car-t/hla-typing-service.htm.

About Creative Biolabs

With more than a decade of exploration and expansion, Creative Biolabs, an established leading expert in TCR and CAR T&NK cell immune therapy development, offers the one-stop custom services that cover the entire new drug development pipeline, including early non-clinical research, process development, pre-clinical animal model testing, cGMP manufacturing, and phase I-III clinical trials.